Facial Filler Comparison Chart

There are a wide variety of dermal fillers in use today. Each has its own unique benefit and purpose. Below is a comparison for general reference purposes. The best thing to do if you are considering injectables or dermal fillers is to consult with a physician.

Below is a reference guide to the most common injectable filler ingredients, the brand names of products that contain them, and important facts as how long the result lasts and the average cost. The key is making sure you get the proper filler for your specific needs―and that you have reasonable expectations.

Injectable fillers/substances and FDA regulation: The U.S. Food and Drug Administration reviews and approves all pharmaceutical fillers and acceptable areas of treatment. Some fillers may be used "off-label" by doctors, meaning for a body part not directly certified by the FDA. Regulatory status for fillers/substances listed above is subject to change:

Filler/Substance	Chemical Composition	Works Best On:	Time it Lasts	Not For Use On:	Inside Tip:	Average Cost
ArteFill	Polymethylmethacrylate microspheres embedded in purified bovine collagen. Lidocaine is also added.	Nasolabial folds, smile lines, wrinkles, lip augmentation.	5-10 years	Lower eyelid, brow area	Artefill’s PMMA particles never break down, making it a”permanent” filler. The collagen around the particles will break down, but the patient’s own collagen will regenerate around the particles.	$1,000 per syringe; roughly 2-3 syringes required per treatment.
Belotero	Monophasic double cross-linked hyaluronic acid	Deep furrows, lip augmentation, facial outlines, naso-labial furrows, glabellar lines, facial depressions	6-9 months	Manufacturersays no risk of ‘lump effects’ so recommended for most areas	Also comes in Soft ( used for perioral wrinkles, lip commissures, crow's feet, and forehead wrinkles) and Intense forms ( deeper lines and wrinkles). Still pending approval by FDA.	$500 per syringe; number of syringes depends on treatment area.
Botox	Botulinum Toxin Type A	Forehead wrinkles, brow lines, crow’s feet, underarm	3-4 months	Deep lines and wrinkles	Botox is only effective for dynamic wrinkles. If you have fine wrinkles, it’s better to try a micro -peel.	$9-13/unit. Cost per treatment in the U.S. averages between $300 and $500.
Cosmoderm/Cosmoplast	Purified human collagen	Fine or deep wrinkles, frown lines, crow’s feet, acne scars, lip lines	2-3 months	Cosmoderm is best used for fine lines; Cosmoplast is best for deeper lines and furrows	Use collagen and hyaluronic acid-based fillers (in combination to replace lost structure and volume.	$300 to $600 per cc.
Dysport	Botulinum Toxin Type A	Forehead wrinkles, brow lines, crow’s feet	3-4 months	Deep wrinkles and folds	Referred to as Botox’s twin, Dysport may actually act faster than Botox, showing results in as soon as 24 hours.	$4 per unit, but 2.5 times as much is needed compare to Botox, making the price about the same.
Evolence	Cross-linked Porcine collagen	Deep facial wrinkles, nasolabial folds, scars, atrophy from disease or trauma	12 months	Around the eyes, breasts, lips	Evolence has a thicker consistency and may cause less bruising in nasolabial fold injections.	$500 or more per syringe; 1-3 syringes used per treatment.
Fat Fillers	Fat cells removed from other parts of the body	Sunken cheeks, thin lips, facial lines, below the eyes, buttocks, (breasts in some cases).	Permanent for fat cells that survive ( 50% of transplanted fat survives 5 years according to studies)	Fat transfer to breasts is controversial. It requires a lot of fat, is quite expensive and results can’t be guaranteed.	Fat transfer is unpredictable. A natural amount is absorbed back into the body after a few months so results can be inconsistent.	$500 to $10,000+ depending on the area and volume injected. Rough estimates are 5 ml - $150, 10 ml - $2000, 20 ml - $3000.
Hylaform	Animal hyaluronic acid gel	Moderate wrinkles, lip enhancement	6-12 months	People with allergies to chickens	Actually derived from rooster combs. Hylaform Plus has a larger gel particle size (similar to Restylane Perlane) and is used for deep lines, facial contouring, and lip enhancement.	$400 per syringe, typically 1-2 syringes per treatment.
Juvederm	3D Hyarulonic acid matrix filler	Nasolabial folds, lip augmentation	Up to one year	Deep wrinkles	Great natural look and great for plumping lips.	$400-$800 per syringe.
Perlane	Hyaluronic acid with bigger molecules	Cheeks, chin, eyebrows, mouth	9-12 months	Thickness makes it less effective for superficial use and could create bumps.	Long lasting and very moldable will hold its shape extremely well in areas that don’t move too much.	$500 - $900 per syringe.
Prevelle Silk	Hyaluronic acid w/lidocaine	Wrinkle reduction, lips.	2-3 months	Deeper folds and those looking for permanent or long-term results.	A bit thinner and softer than other hyarulonic acids so doesn’t last as long. Results are also more immediate. Lidocaine also helps with pain.	$250 per syringe, but roughly twice as much needed as Restylane or Juvederm making the cost about the same.
Restylane	Hyaluronic acid	Nasolabial folds, smile lines, brow lines, lips, beneath the eyes.	6-8 months	Deeper folds - smaller molecule make it less effective.	Great “starter” filler –not long-lasting so good to try out a look.	$500-$700 per syringe.
Radiesse	Calcium hydroxyapatite particles suspended in hyaluronic gel.	Smile and marionette lines, cheeks, broader, deeper folds.	12-18 months	Lip augmentation. Radiesse is a thicker filler and will likely cause lumpiness in the lips.	Radiesse is a filler made up of the same composition as bone and can’t be reversed.	Depending on the size of the syringe, between $400-$800.
Sculptra	Poly-L-lactic acid	Deep folds between nose and mouth, folds around corners of mouth, sunken cheeks/chin, wrinkling on cheeks/chin, deep scars	Up to 2 years	Injections close to the surface of the skin – can leave small bumps.	Stimulates production of your own collagen.	$800-$1,000 per vial. Average is two to three treatments needed.
Zyderm/Zyplast	Purified bovine collagen w/ lidocaine	Crow’s feet, scars, lip lines	3-4 months	People allergic to cow products or lidocaine.	Zyderm and Zyplast are the oldest fillers, having been introduced in the early 80s, and are rarely used anymore.	$300-$400 per cc.